Is San Francisco safer than Durham?
Yes. San Francisco's crime index is 183 versus 193 in Durham, and its violent crime index is 156 versus 163, using 2024-2025 FBI data.
Durham is cheaper. Median rent is $1,508 a month versus $2,476 in San Francisco.
The income gap between San Francisco and Durham is significant: $140,970 median household versus $81,619. That spread matters more if you are job hunting locally than if you are remote. Typical rent is $2,476 in San Francisco and $1,508 in Durham.
San Francisco is not a close call here. It leads on the job market, safety, and weather by margins that add up in daily life. Durham makes sense if you have a specific reason, a job offer, family, or a neighborhood you already know, but on the numbers alone San Francisco is the stronger move.
The rent gap is real but neighborhoods matter. Durham at $1,508 average has pockets that run $1,308 and others at $1,908: your actual number depends on which part of the city you land in.