Rent
Neck and neck
Santa Ana and Winston Salem are about even on rent.
Santa Ana
$2,150/mo
Winston Salem
$2,150/mo
What this means for your life
Typical rent in Santa Ana is $2,150 a month versus $2,150 in Winston Salem, close enough that housing cost should not decide the move by itself. Factor it into your budget alongside salary differences between the two markets, then pick the city that wins the categories you actually live in: safety, schools, pay, or weather.